Viral ion channel: Structure and function of influenza virus M2 protein.
نویسندگان
چکیده
منابع مشابه
Influenza A Virus M2 Ion Channel Protein:
A structure-function analysis of the influenza A virus M2 ion channel protein was performed. The M2 protein of human influenza virus A/Udorn/72 and mutants containing changes on one face of the putative a helix of the M2 transmembrane (TM) domain, several of which lead to amantadine resistance when found in virus, were expressed in oocytes of Xenopus laevis. The membrane currents of oocytes exp...
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Background and Aims: Influenza A virus of Orthomyxoviridae family is able to create pandemic influenza. Vaccination is the most effective way to prevent influenza virus infection. Matrix protein 2 (M2) is a homotetramer ion channel with 97 amino acids length and highly conserved among influenza viruses and is considered for development of a universal influenza vaccine. Materials and Methods: We...
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Influenza virus is responsible for annual epidemics that cause severe illness in ~5 million people worldwide. Evidence has shown that influenza infection engages the NLRP3 inflammasome complex in dendritic cells and macrophages1–4. NLRP3 forms a multiprotein complex with the adaptor protein ASC (pycard) and caspase-1, which leads to the catalytic cleavage of the immature (‘pro’) forms of interl...
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The M2 protein of influenza A viruses forms a tetrameric pH-activated proton-selective channel that is targeted by the amantadine class of antiviral drugs. Its ion channel function has been extensively studied by electrophysiology and mutagenesis; however, the molecular mechanism of proton transport is still elusive, and the mechanism of inhibition by amantadine is controversial. We review the ...
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Influenza A virus poses serious health threat to humans. Neutralizing antibodies against the highly conserved M2 ion channel is thought to offer broad protection against influenza A viruses. Here, we screened synthetic Camel single-domain antibody (VHH) libraries against native M2 ion channel protein. One of the isolated VHHs, M2-7A, specifically bound to M2-expressed cell membrane as well as i...
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ژورنال
عنوان ژورنال: Uirusu
سال: 1997
ISSN: 0042-6857,1884-3433
DOI: 10.2222/jsv.47.177